2017 Global survey on nebulization of antimicrobial agents in mechanically ventilated patients—SANEME 2 study protocol

Antimicrobial agents are increasingly administered by aerosol for therapy of respiratory infections in mechanically ventilated (MV) patients. A prior survey was undertaken to reveal how they are used worldwide, in December 2014. Respondents from 192 intensive care units (ICUs) completed a structured online questionnaire, consisting of questions regarding aerosol antimicrobials patterns (in the prior week) and indications, as well as antimicrobial dosage for MV adults. We plan a follow up a new survey in 2017, with more significant representation of ICUs in key regional areas. It is expected to have information: (I) on the most common indications for nebulization; (II) the most commonly aerosolized antibiotics and daily doses prescribed for VAP and VAT; (III) changes in prescription patterns. This global survey will provide regional information on current practices, particularly indications, dosing and antibiotic combinations to improve clinical outcomes. The 2017 study protocol is reported herein.