Sepsis, the earlier the better, 3- to 1-hour bundle

Sepsis is life threatening organ dysfunction caused by a dysregulated host response to infection. There is a substantial global burden in sepsis with an estimated 32 million cases and 5.3 million deaths per year (1). Its prevalence is increasing, and it is associated with high costs and poor outcomes. From 2010 to 2015 the proportion of admissions for sepsis in the United States more than doubled from 3.9% to 9.4% (2). This is leading to increasing hospital expenditure, more than $20 billion per year in the United States (3).