Original Article
Efficacy and safety of intravenous oxycodone for general anesthesia in children
Abstract
Background: Oxycodone had been widely used for cancer pain control and postoperative pain control. However, its efficacy and safety for general anesthesia in pediatric patients have not been reported. The study aimed to investigate the analgesic effect and safety of oxycodone as compared to sulfentanil.
Methods: This was a retrospective study conducted in a tertiary care medical center. In the oxycodone group, anesthesia was induced by propofol (3 mg/kg), cisatracurium (0.1–0.15 mg/kg) and oxycodone (0.2–0.4 mg/kg). In the control group, the oxycodone was replaced by sulfentanil (0.3–0.6 ug/kg). Both groups had remifentanil (11–13 ug/kg/hr) administered continuously via intravenous pump during operation. Anesthesia was maintained by propofol (6–9 mg/kg/hr) and cisatracurium (0.05–0.1 mg/kg/hr) in all patients.
Results: A total of 94 children fulfilled our inclusion criteria and were used for analysis. There was no significant difference in demographics and baseline characteristics between oxycodone and control groups. Propofol and ramifentanil doses for anesthesia maintenance were similar between both groups. Postoperative analgesic uses were slightly higher in the control group than oxycodone group (27.6% vs. 20.0%; P=0.636). The incidence of adverse events including nausea, vomiting tended to be higher in the control group (26.1% vs. 12%; P=0.147).
Conclusions: The results showed that oxycodone had comparable analgesic effect to sulfentanil, and tended to have lower postoperative analgesic requirement and less adverse events.
Methods: This was a retrospective study conducted in a tertiary care medical center. In the oxycodone group, anesthesia was induced by propofol (3 mg/kg), cisatracurium (0.1–0.15 mg/kg) and oxycodone (0.2–0.4 mg/kg). In the control group, the oxycodone was replaced by sulfentanil (0.3–0.6 ug/kg). Both groups had remifentanil (11–13 ug/kg/hr) administered continuously via intravenous pump during operation. Anesthesia was maintained by propofol (6–9 mg/kg/hr) and cisatracurium (0.05–0.1 mg/kg/hr) in all patients.
Results: A total of 94 children fulfilled our inclusion criteria and were used for analysis. There was no significant difference in demographics and baseline characteristics between oxycodone and control groups. Propofol and ramifentanil doses for anesthesia maintenance were similar between both groups. Postoperative analgesic uses were slightly higher in the control group than oxycodone group (27.6% vs. 20.0%; P=0.636). The incidence of adverse events including nausea, vomiting tended to be higher in the control group (26.1% vs. 12%; P=0.147).
Conclusions: The results showed that oxycodone had comparable analgesic effect to sulfentanil, and tended to have lower postoperative analgesic requirement and less adverse events.
